反应详情

Ethyl 2,4-difluorobenzoate (1.14 g), K3PO4 (1.30 g) and 5-hydroxyindazole (0.90 g) were stirred at 110° C. in diglyme (12 mL) for 24 hours. The reaction was cooled and poured into ether. The solution was washed three times with 1M NaOH solution, and brine, and dried. The solution was then concentrated, and the crude product was chromatographed on silica gel with 20% ethyl acetate/hexanes.

1. temperatureThe reaction was cooled
2. washThe solution was washed three times with 1M NaOH solution, and brine
3. customdried
4. concentrationThe solution was then concentrated
5. customthe crude product was chromatographed on silica gel with 20% ethyl acetate/hexanes