反应详情

To 15 mL of tetrahydrofuran (THF) at 0° C. was added LiAlH4 (0.28 g, 7.3 mmol). This mixture was stirred for 10 min then the ethyl tetrahydropyran-4-yl-acetate (Combi-Blocks Inc., 0.50 g, 2.9 mmol) was added. The reaction was stirred for 5 min at 0° C. then was allowed to warm to ambient temperature and was stirred for 90 min. The reaction was quenched with excess NaHSO4.10H2O and was stirred for 60 min. The mixture was filtered through Celite. The filtrate was concentrated to give the title compound which was carried on without further purification. MS (DCI/NH3) m/z 131 (M+H)+.

1. stirringThe reaction was stirred for 5 min at 0° C.
2. stirringwas stirred for 90 min
3. customThe reaction was quenched with excess NaHSO4.10H2O
4. stirringwas stirred for 60 min
5. filtrationThe mixture was filtered through Celite
6. concentrationThe filtrate was concentrated