Hydrochloric Acid → HCID 79005005, compound

HRID 2273780Notes

Reaction equation

HRID 2273780 reaction equation
[F:1][CH:2]([F:17])[CH2:3][N:4]1[CH2:8][CH2:7][C@@H:6]([NH:9]C(=O)OC(C)(C)C)[CH2:5]1.Cl>ClCCl.CO.O1CCOCC1>[F:1][CH:2]([F:17])[CH2:3][N:4]1[CH2:8][CH2:7][C@@H:6]([NH2:9])[CH2:5]1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 86642506HCID 86642506, compound

Product 1

HCID 79005005HCID 79005005, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of EXAMPLE 407A (525 mg) in a mixture of dichloromethane (3 mL) and methanol (2.0 mL) was added hydrogen chloride, 4M in dioxane (5.24 mL). The reaction was stirred for 3 hours, and concentrated to provide the title compound.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-2ea5331521c64924b6dd92a1fb1876fc
Source dataset
uspto-grants-2015_09
Patent number
US09125913B2

Reaction notes

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