Diisopropylethylamine → HCID 67169233, compound

HRID 2273797Notes

Reaction equation

HRID 2273797 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:5]=[N:6][C:7]=1Cl.[CH:13]1([N:16]2[CH2:21][CH2:20][CH:19]([NH2:22])[CH2:18][CH2:17]2)[CH2:15][CH2:14]1.C(N(CC)C(C)C)(C)C>O1CCOCC1>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:5]=[N:6][C:7]=1[NH:22][CH:19]1[CH2:20][CH2:21][N:16]([CH:13]2[CH2:15][CH2:14]2)[CH2:17][CH2:18]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 47309215,6-Dichloropyridine-3-sulfonamideHCID 162276441-Cyclopropylpiperidin-4-amine

Product 1

HCID 67169233HCID 67169233, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of EXAMPLE 387A (0.4 g), 1-cyclopropylpiperidin-4-amine (0.3 g) and N,N-diisopropylethylamine (0.37 mL) in dioxane (3 mL) was heated at 100° C. for 18 hours. The crude product was isolated by concentration and was purified on silica gel, which was eluted with ethyl acetate to give the title compound.

Workup

  1. customThe crude product was isolated by concentration
  2. customwas purified on silica gel, which
  3. washwas eluted with ethyl acetate

Sources & evidence

ORD record
ord-efb82afcec7449529df21fda6ccf2db1
Source dataset
uspto-grants-2015_09
Patent number
US09125913B2

Reaction notes

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