Trifluoroacetic acid → HCID 178511076, compound

HRID 2273800Notes

Reaction equation

HRID 2273800 reaction equation
C(OC(=O)[NH:7][CH2:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([CH2:15][C:16]#[N:17])[CH2:11][CH2:10]1)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:7][CH2:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([CH2:15][C:16]#[N:17])[CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453593HCID 178453593, compound

Product 1

HCID 178511076HCID 178511076, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl(trans-4-(cyanomethyl)cyclohexyl)methylcarbamate (500 mg) in dichloromethane (5 mL) was slowly added trifluoroacetic acid (3 mL) at 0° C. The mixture was warmed to room temperature, stirred for 1 hour. The title compound was obtained by concentration.

Workup

  1. customat 0° C

Sources & evidence

ORD record
ord-bc471b1618e34e9e8a925ddc07727247
Source dataset
uspto-grants-2015_09
Patent number
US09125913B2

Reaction notes

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