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HRID2274140

反应详情

EQUATION

反应方程式

HRID 2274140 的结构方程式

REACTANTS

反应物

1
结构：COc1ccc(COc2nc(OCc3ccc(OC)cc3)c3ccc(N4CCOCC4)cc3n2)cc1
HCID67401418

未命名化合物

PRODUCTS

生成物

1
结构：O=c1[nH]c(=O)c2ccc(N3CCOCC3)cc2[nH]1
HCID13499298

未命名化合物

收率 94.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1.Cl
溶剂HCID20443148

1,4-Dioxane hydrochloride

C4H9ClO2

PROCEDURE

实验过程

232.0 g (0.48 mol) of 2,4-bis(4-methoxybenzyloxy)-7-morpholin-4-ylquinazoline were dissolved in 300 ml of hydrogen chloride/dioxane (4 N) at room temperature and stirred for 3 h. Conventional work-up gave 112.5 g of 7-morpholin-4-yl-1H-quinazoline-2,4-dione; HPLC/MS (M+H)+=248 as solid.