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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2274140Generated: October 31, 2026

2,4-Bis(4-methoxybenzyloxy)-7-morpholin-4-ylquinazoline → 7-morpholinoquinazoline-2,4(1H,3H)-dione

https://huagongshe.com/reaction/2274140

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,4-Bis(4-methoxybenzyloxy)-7-morpholin-4-ylquinazolineHCID 67401418—
Solvent1,4-Dioxane hydrochlorideHCID 20443148—
Product7-morpholinoquinazoline-2,4(1H,3H)-dioneHCID 1349929894.8%

Reaction Steps

232.0 g (0.48 mol) of 2,4-bis(4-methoxybenzyloxy)-7-morpholin-4-ylquinazoline were dissolved in 300 ml of hydrogen chloride/dioxane (4 N) at room temperature and stirred for 3 h. Conventional work-up gave 112.5 g of 7-morpholin-4-yl-1H-quinazoline-2,4-dione; HPLC/MS (M+H)+=248 as solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09126952B2
Source datasetuspto-grants-2015_09
ORD IDord-735f5ee22127435cac217eee255b1ba4
Source noteuspto-grants-2015_09