4-(4-Methoxybenzyloxy)-7-morpholin-4-ylquinazoline → 7-(Morpholin-4-yl)quinazolin-4(3H)-one

HRID 2274145Notes

Reaction equation

HRID 2274145 reaction equation
COC1C=CC(C[O:8][C:9]2[C:18]3[C:13](=[CH:14][C:15]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)=[CH:16][CH:17]=3)[N:12]=[CH:11][N:10]=2)=CC=1>Cl.O1CCOCC1>[N:19]1([C:15]2[CH:14]=[C:13]3[C:18]([C:9](=[O:8])[NH:10][CH:11]=[N:12]3)=[CH:17][CH:16]=2)[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1

Participants

3

Reactant 1

HCID 674026574-(4-Methoxybenzyloxy)-7-morpholin-4-ylquinazoline

Product 1

HCID 1357423607-(Morpholin-4-yl)quinazolin-4(3H)-oneYield 129.7%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

178 g (0.15 mol) of 4-(4-methoxybenzyloxy)-7-morpholin-4-ylquinazoline were dissolved in 250 ml of hydrogen chloride/dioxane (4 N) at room temperature and stirred for 3 h. Conventional work-up gave 45.0 g of 7-morpholin-4-yl-3H-quinazolin-4-one as solid.

Sources & evidence

ORD record
ord-b232014c60794f6c862ac687271debbf
Source dataset
uspto-grants-2015_09
Patent number
US09126952B2

Reaction notes

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