HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Methoxybenzyloxy)-7-morpholin-4-ylquinazoline → 7-(Morpholin-4-yl)quinazolin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Methoxybenzyloxy)-7-morpholin-4-ylquinazoline | HCID 67402657 | — |
| Solvent | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | 7-(Morpholin-4-yl)quinazolin-4(3H)-one | HCID 135742360 | 129.7% |
Reaction Steps
178 g (0.15 mol) of 4-(4-methoxybenzyloxy)-7-morpholin-4-ylquinazoline were dissolved in 250 ml of hydrogen chloride/dioxane (4 N) at room temperature and stirred for 3 h. Conventional work-up gave 45.0 g of 7-morpholin-4-yl-3H-quinazolin-4-one as solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126952B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-b232014c60794f6c862ac687271debbf |
| Source note | uspto-grants-2015_09 |