Formamidine acetate → 7-(Morpholin-4-yl)quinazolin-4(3H)-one

HRID 2274148Notes

Reaction equation

HRID 2274148 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.C(O)(=O)C.[CH:21](N)=[NH:22]>C(O)C>[N:11]1([C:9]2[CH:10]=[C:2]3[C:3]([C:4](=[O:6])[NH:22][CH:21]=[N:1]3)=[CH:7][CH:8]=2)[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 160693Formamidine acetateHCID 178082042-Amino-4-(morpholin-4-yl)benzoic acid

Product 1

HCID 1357423607-(Morpholin-4-yl)quinazolin-4(3H)-oneYield 50.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4.22 g (0.019 mol) of 2-amino-4-morpholin-4-ylbenzoic acid and 4.0 g (0.038 mol) of formamidine acetate were suspended in 40 ml of ethanol. The reaction mixture was subsequently stirred under reflux for 16 h. Conventional work-up gave 2.2 g (Y=50%) of 7-morpholin-4-yl-3H-quinazolin-4-one.

Workup

  1. temperatureunder reflux for 16 h

Sources & evidence

ORD record
ord-bb12a4705c6e4881b52d4b2d11d9ce97
Source dataset
uspto-grants-2015_09
Patent number
US09126952B2

Reaction notes

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