HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamidine acetate → 7-(Morpholin-4-yl)quinazolin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamidine acetate | HCID 160693 | — |
| Reactant | 2-Amino-4-(morpholin-4-yl)benzoic acid | HCID 17808204 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-(Morpholin-4-yl)quinazolin-4(3H)-one | HCID 135742360 | 50.1% |
Reaction Steps
4.22 g (0.019 mol) of 2-amino-4-morpholin-4-ylbenzoic acid and 4.0 g (0.038 mol) of formamidine acetate were suspended in 40 ml of ethanol. The reaction mixture was subsequently stirred under reflux for 16 h. Conventional work-up gave 2.2 g (Y=50%) of 7-morpholin-4-yl-3H-quinazolin-4-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126952B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-bb12a4705c6e4881b52d4b2d11d9ce97 |
| Source note | uspto-grants-2015_09 |