Morpholine → 7-(Morpholin-4-yl)quinazolin-4(3H)-one

HRID 2274150Notes

Reaction equation

HRID 2274150 reaction equation
F[C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:12])[NH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>>[N:13]1([C:2]2[CH:11]=[C:10]3[C:5]([C:6](=[O:12])[NH:7][CH:8]=[N:9]3)=[CH:4][CH:3]=2)[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 1353984967-Fluoroquinazolin-4(3H)-one

Product 1

HCID 1357423607-(Morpholin-4-yl)quinazolin-4(3H)-oneYield 50%

Conditions

Temperature
90 °C

Procedure

20.0 g (0.122 mol) of 7-fluoro-3H-quinazolin-4-one were suspended in 80 ml of morpholine and stirred at an internal temperature of 90° C. for 16 h. Conventional work-up gave 14.1 g (Y=50%) of 7-morpholin-4-yl-3H-quinazolin-4-one (as described in Example 2.2, reaction step 1a).

Sources & evidence

ORD record
ord-9f8e0088a4834da5b5addd2d6527216a
Source dataset
uspto-grants-2015_09
Patent number
US09126952B2

Reaction notes

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