Morpholine → 6-fluoro-7-morpholin-4-yl-3H-quinazolin-4-one

HRID 2274152Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1F)[N:8]=[CH:7][NH:6][C:5]2=[O:13].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)[N:8]=[CH:7][NH:6][C:5]2=[O:13]

Participants

Reactant 2

HCID 8083Morpholine

HCID 1354713086,7-Difluoroquinazolin-4(3H)-one

Product 1

HCID 1360002446-fluoro-7-morpholin-4-yl-3H-quinazolin-4-oneYield 74.8%

Conditions

Temperature: 80 °C

Procedure

37.2 g (0.20 mol) of 6,7-difluoro-3H-quinazolin-4-one were suspended in 70 ml (0.80 mol) of morpholine and stirred at an internal temperature of 80° C. for 16 h. Conventional work-up gave 37.3 g (Y=74%) of 6-fluoro-7-morpholin-4-yl-3H-quinazolin-4-one.

Sources & evidence

ORD record: ord-d8bd7c471e8e43ab91c17c69264068a9
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09126952B2

Reaction notes

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