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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2274152Generated: October 30, 2026

Morpholine → 6-fluoro-7-morpholin-4-yl-3H-quinazolin-4-one

https://huagongshe.com/reaction/2274152

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMorpholineHCID 8083—
Reactant6,7-Difluoroquinazolin-4(3H)-oneHCID 135471308—
Product6-fluoro-7-morpholin-4-yl-3H-quinazolin-4-oneHCID 13600024474.8%

Reaction Conditions

Temperature80 °C

Reaction Steps

37.2 g (0.20 mol) of 6,7-difluoro-3H-quinazolin-4-one were suspended in 70 ml (0.80 mol) of morpholine and stirred at an internal temperature of 80° C. for 16 h. Conventional work-up gave 37.3 g (Y=74%) of 6-fluoro-7-morpholin-4-yl-3H-quinazolin-4-one.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09126952B2
Source datasetuspto-grants-2015_09
ORD IDord-d8bd7c471e8e43ab91c17c69264068a9
Source noteuspto-grants-2015_09