反应详情

443 mg of 4-fluoro-2-nitro-5-(2-piperidin-1-ylethoxy)-phenylamine in solution in 20 mL of methanol are hydrogenated under 1 bar of hydrogen pressure in the presence of 44 mg of palladium-on-charcoal at 25° C. for 10 hours. The reaction crude is filtered through celite and the filtrate is concentrated under vacuum in a rotary evaporator. 380 mg of 4-fluoro-5-(2-piperidin-1-ylethoxy)benzene-1,2-diamine are obtained in the form of a black lake. The compound is used without any other purification.

1. customThe reaction crude
2. filtrationis filtered through celite
3. concentrationthe filtrate is concentrated under vacuum in a rotary evaporator