HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-2-nitro-5-(2-piperidin-1-ylethoxy)-phenylamine → 4-Fluoro-5-(2-piperidin-1-ylethoxy)benzene-1,2-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-2-nitro-5-(2-piperidin-1-ylethoxy)-phenylamine | HCID 68842103 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Fluoro-5-(2-piperidin-1-ylethoxy)benzene-1,2-diamine | HCID 68841997 | 95.9% |
Reaction Steps
443 mg of 4-fluoro-2-nitro-5-(2-piperidin-1-ylethoxy)-phenylamine in solution in 20 mL of methanol are hydrogenated under 1 bar of hydrogen pressure in the presence of 44 mg of palladium-on-charcoal at 25° C. for 10 hours. The reaction crude is filtered through celite and the filtrate is concentrated under vacuum in a rotary evaporator. 380 mg of 4-fluoro-5-(2-piperidin-1-ylethoxy)benzene-1,2-diamine are obtained in the form of a black lake. The compound is used without any other purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126969B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-f960b1c2438d4fea81fa247729c7257c |
| Source note | uspto-grants-2015_09 |