Triphosgene → HCID 71001847, compound

HRID 2274461Notes

Reaction equation

HRID 2274461 reaction equation
Cl[C:2](Cl)([O:4]C(=O)OC(Cl)(Cl)Cl)Cl.[CH2:13]([NH:15][C:16]1[CH:24]=[C:23]([I:25])[CH:22]=[CH:21][C:17]=1[C:18]([OH:20])=[O:19])[CH3:14]>O1CCOCC1>[CH2:13]([N:15]1[C:16]2[CH:24]=[C:23]([I:25])[CH:22]=[CH:21][C:17]=2[C:18](=[O:20])[O:19][C:2]1=[O:4])[CH3:14]

Participants

4

Reactant 2

HCID 94429TriphosgeneHCID 71001823HCID 71001823, compound

Product 1

HCID 71001847HCID 71001847, compoundYield 283%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
110 °C

Procedure

0.785 g (2.65 mmol) of triphosgene were added at room temperature to 2.2 g (7.55 mmol) of 2-ethylamino-4-iodo-benzoic acid in 30 ml of dioxane. The reaction mixture was then heated and stirred at 110° C. during 2 hours. The solution was evaporated to dryness and reevaporated twice after 2 additions of 20 ml of toluene to give 2.39 g (7.5 mmol) of a solid.

Workup

  1. temperatureThe reaction mixture was then heated
  2. customThe solution was evaporated to dryness
  3. customreevaporated twice after 2 additions of 20 ml of toluene

Sources & evidence

ORD record
ord-ef3f96c6583f42e9a79435c5737bd06e
Source dataset
uspto-grants-2015_09
Patent number
US09126972B2

Reaction notes

Loading…