4-(Bromomethyl)-1,2-difluorobenzene → (4-(3,4-Difluorobenzyl)morpholin-2-yl)methanamine

HRID 227453Notes

Reaction equation

HRID 227453 reaction equation
ClC1SC(C[N:8]2[CH2:13][CH2:12][O:11][CH:10]([CH2:14][NH2:15])[CH2:9]2)=CC=1.[F:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:20]Br>>[F:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:20][N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][NH2:15])[CH2:9]1

Participants

3

Reactant 2

HCID 5814364-(Bromomethyl)-1,2-difluorobenzeneHCID 219628881-[4-[(5-Chlorothien-2-yl)methyl]morpholin-2-yl]methanamine

Product 1

HCID 21962864(4-(3,4-Difluorobenzyl)morpholin-2-yl)methanamine

Procedure

Intermediate 20 was prepared in an analogous manner to Intermediate 1 (Alternative Procedure) from Intermediate 19 and 3,4-difluorobenzyl bromide, followed by deprotection to yield the title compound.

Sources & evidence

ORD record
ord-eeb9e02a9a3c4f57a7b54b4477e674cc
Source dataset
uspto-grants-2009_07
Patent number
US07560548B2

Reaction notes

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