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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 227454Generated: October 25, 2026

4-Fluorobenzyl chloride → 2-Aminomethyl-4-(4-fluorobenzyl)morpholine

https://huagongshe.com/reaction/227454

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluorobenzyl chlorideHCID 9602—
Reactant1-[4-[(5-Chlorothien-2-yl)methyl]morpholin-2-yl]methanamineHCID 21962888—
Product2-Aminomethyl-4-(4-fluorobenzyl)morpholineHCID 10242735—

Reaction Steps

Intermediate 21 was prepared in an analogous manner to Intermediate 1 (Alternative Procedure) from Intermediate 19 and 4-fluorobenzyl chloride, followed by deprotection to yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07560548B2
Source datasetuspto-grants-2009_07
ORD IDord-9fb28083130f4a578454c78ca1b2208c
Source noteuspto-grants-2009_07