4-Fluorobenzyl chloride → 2-Aminomethyl-4-(4-fluorobenzyl)morpholine

HRID 227454Notes

Reaction equation

HRID 227454 reaction equation
ClC1SC(C[N:8]2[CH2:13][CH2:12][O:11][CH:10]([CH2:14][NH2:15])[CH2:9]2)=CC=1.[F:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21]Cl)=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:24]=[CH:23][C:20]([CH2:21][N:8]2[CH2:13][CH2:12][O:11][CH:10]([CH2:14][NH2:15])[CH2:9]2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 96024-Fluorobenzyl chlorideHCID 219628881-[4-[(5-Chlorothien-2-yl)methyl]morpholin-2-yl]methanamine

Product 1

HCID 102427352-Aminomethyl-4-(4-fluorobenzyl)morpholine

Procedure

Intermediate 21 was prepared in an analogous manner to Intermediate 1 (Alternative Procedure) from Intermediate 19 and 4-fluorobenzyl chloride, followed by deprotection to yield the title compound.

Sources & evidence

ORD record
ord-9fb28083130f4a578454c78ca1b2208c
Source dataset
uspto-grants-2009_07
Patent number
US07560548B2

Reaction notes

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