Methanol → HCID 22591541, compound

HRID 22746Notes

Reaction equation

HRID 22746 reaction equation
[Na].CO[C:4]1[N:5]=[N:6][C:7]([S:10]([C:13]2[N:14](S(C3C=CC=CC=3)(=O)=O)[C:15]3[C:20]([CH:21]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)(=[O:12])=[O:11])=[CH:8][CH:9]=1.[CH3:31][OH:32]>>[CH3:31][O:32][N:5]1[CH:4]=[CH:9][CH:8]=[C:7]([S:10]([C:13]2[NH:14][C:15]3[C:20]([CH:21]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)(=[O:11])=[O:12])[NH:6]1

Participants

4

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 22591544HCID 22591544, compound

Product 1

HCID 22591541HCID 22591541, compoundYield 82%

Procedure

To a solution of sodium metal (18.6 mmol, 428 mg) dissolved in methanol (8 mL) was added a solution of 3-methoxy-6-(N-phenylsulfonylindole-2-sulfonyl)-pyridazine (1.86 mmol, 850 mg) and the reaction was stirred for 10 minutes. The reaction mixture was quenched with H2O (10 mL) and CHCl3 (25 mL). The CHCl3 layer was collected, dried, filtered, and the filtrate was evaporated to obtain 2-methoxy-6-(indole-2-sulfonyl)-pyridazine (82%, 440 mg).

Workup

  1. customThe reaction mixture was quenched with H2O (10 mL) and CHCl3 (25 mL)
  2. customThe CHCl3 layer was collected
  3. customdried
  4. filtrationfiltered
  5. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-de1930df1bd64b88b868e45eee6f541d
Source dataset
uspto-grants-2005_02
Patent number
US06849629B2

Reaction notes

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