Lithium hydroxide, monohydrate → HCID 67304491, compound

HRID 2274624Notes

Reaction equation

HRID 2274624 reaction equation
[CH2:1]([NH:8][C:9](=[O:20])[NH:10][CH2:11][C:12]([CH3:19])([CH3:18])[C:13]([O:15]CC)=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[OH-].[Li+]>>[CH2:1]([NH:8][C:9](=[O:20])[NH:10][CH2:11][C:12]([CH3:18])([CH3:19])[C:13]([OH:15])=[O:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 67303715HCID 67303715, compound

Product 1

HCID 67304491HCID 67304491, compoundYield 50.7%

Procedure

According to the procedure described in the synthesis method of Compound VI-1, ethyl 3-(3-benzylureido)-2,2-dimethylpropanoate (Compound V-4) (840 mg, 3.0 mmol) was reacted with lithium hydroxide monohydrate (151 mg, 3.6 mmol) to obtain the title compound (381 mg, 50.7%).

Sources & evidence

ORD record
ord-71ccc6473d4848278024e9ab301dce46
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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