1,4-Dioxane hydrochloride → 2-(3-(Naphthalen-1-ylmethyl)ureidooxy)acetic acid

HRID 2274630Notes

Reaction equation

HRID 2274630 reaction equation
[C:1]1([CH2:11][NH:12][C:13](=[O:24])[NH:14][O:15][CH2:16][C:17]([O:19]C(C)(C)C)=[O:18])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.Cl.O1CCOCC1>>[C:1]1([CH2:11][NH:12][C:13](=[O:24])[NH:14][O:15][CH2:16][C:17]([OH:19])=[O:18])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86658801HCID 86658801, compound

Product 1

HCID 533975382-(3-(Naphthalen-1-ylmethyl)ureidooxy)acetic acidYield 100%

Procedure

According to the procedure described in the synthesis method of Compound VI-9, tert-butyl 2-(3-(naphthalen-1-ylmethyl)ureidooxy)acetate (Compound V-7) (50 mg, 0.15 mmol) was reacted with 4N HCl/dioxane (2 ml) to obtain the title compound (41 mg, 100%).

Sources & evidence

ORD record
ord-d58831a1cb5f4f45b2b66f728d152a17
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

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