1,4-Dioxane hydrochloride → 2-(3-Ethylureidooxy)acetic acid

HRID 2274631Notes

Reaction equation

HRID 2274631 reaction equation
[CH2:1]([NH:3][C:4](=[O:15])[NH:5][O:6][CH2:7][C:8]([O:10]C(C)(C)C)=[O:9])[CH3:2].Cl.O1CCOCC1>>[CH2:1]([NH:3][C:4](=[O:15])[NH:5][O:6][CH2:7][C:8]([OH:10])=[O:9])[CH3:2]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86658798HCID 86658798, compound

Product 1

HCID 533974162-(3-Ethylureidooxy)acetic acidYield 100%

Procedure

According to the procedure described in the synthesis method of Compound VI-9, tert-butyl 2-(3-ethylureidooxy)acetate (Compound V-8) (33 mg, 0.15 mmol) was reacted with 4N HCl/dioxane (2 ml) to obtain the title compound (24 mg, 100%).

Sources & evidence

ORD record
ord-168772e7c6f24df69f9b6bfbb0d706fe
Source dataset
uspto-grants-2015_09
Patent number
US09126981B2

Reaction notes

Loading…