HRID2274685

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8082

Piperidine

C5H11N

结构：CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)OCC1c2ccccc2-c2ccccc21

HCID86698528

未命名化合物

PRODUCTS

生成物

结构：CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1

HCID67075252

未命名化合物

收率 98%

PROCEDURE

实验过程

According to the procedure described in the synthesis method of Compound IV-1, (9H-fluoren-9-yl)methyl(S)-1-((benzo[b]thiophen-3-ylmethyl)((S)-1,1-diethoxypropan-2-yl)amino)-3-(4-tert-butoxyphenyl)-1-oxopropan-2-ylcarbamate (Compound III-10)(500 mg, 0.68 mmol) was treated with piperidine and the obtained residue was purified by silica gel column chromatography (eluent: n-hexane:ethyl acetate=9:1, chloroform:methanol=100:0 and 8:2) to obtain the title compound (339 mg, 98%).

WORKUP

后处理

customthe obtained residue was purified by silica gel column chromatography (eluent: n-hexane:ethyl acetate=9:1, chloroform:methanol=100:0 and 8:2)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fb8de4204bea4012806a4b32ff89716d
来源数据集: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09126981B2
来源说明: uspto-grants-2015_09

反应 SMILES

[S:1]1[CH:5]=[C:4]([CH2:6][N:7]([C@@H:41]([CH3:49])[CH:42]([O:46][CH2:47][CH3:48])[O:43][CH2:44][CH3:45])[C:8](=[O:40])[C@@H:9]([NH:22]C(=O)OCC2C3C=CC=CC=3C3C2=CC=CC=3)[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:13][CH:12]=2)[C:3]2[CH:50]=[CH:51][CH:52]=[CH:53][C:2]1=2.N1CCCCC1>>[NH2:22][C@@H:9]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]([CH3:21])([CH3:19])[CH3:20])=[CH:13][CH:12]=1)[C:8]([N:7]([CH2:6][C:4]1[C:3]2[CH:50]=[CH:51][CH:52]=[CH:53][C:2]=2[S:1][CH:5]=1)[C@@H:41]([CH3:49])[CH:42]([O:46][CH2:47][CH3:48])[O:43][CH2:44][CH3:45])=[O:40]