Sodium Hydroxide → HCID 71294571, compound

HRID 2274713Notes

Reaction equation

HRID 2274713 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5]/[CH:6]=[CH:7]\[CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH:18]([OH:40])[CH2:19][CH:20]([OH:39])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]/[CH:29]=[CH:30]\[CH2:31]/[CH:32]=[CH:33]\[CH2:34][CH2:35][CH2:36][CH2:37][CH3:38].C(O[CH:44](OCC)[CH2:45][CH2:46][CH2:47][N:48]([CH3:50])[CH3:49])C.CC1C=CC(S([O-])(=O)=O)=CC=1.C1C=C[NH+]=CC=1.[OH-].[Na+]>C1(C)C=CC=CC=1>[CH2:17]([CH:18]1[CH2:19][CH:20]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]/[CH:29]=[CH:30]\[CH2:31]/[CH:32]=[CH:33]\[CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[O:39][CH:44]([CH2:45][CH2:46][CH2:47][N:48]([CH3:50])[CH3:49])[O:40]1)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]/[CH:10]=[CH:9]\[CH2:8]/[CH:7]=[CH:6]\[CH2:5][CH2:4][CH2:3][CH2:2][CH3:1]

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 5470784,4-Diethoxy-N,N-dimethyl-1-butanamineHCID 86678087HCID 86678087, compound

Product 1

HCID 71294571HCID 71294571, compoundYield 68.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

A solution of the diol (6Z,9Z,29Z,32Z)-octatriaconta-6,9,29,32-tetraene-18,20-diol (7) (500 mg, 0.89 mmol) and 4,4-Diethoxy-N,N-dimethyl-1-butanamine (301mL, 1.34 mmol) in toluene (10 mL) was treated with PPTS (671 mg, 2.67 mmol) and heated (80° C.). After stirring (1 h) the solution was poured into NaOH (5M aq.) and extracted with CH2Cl2. The organic layer was washed with brine, dried (Na2SO4), filtered and concentrated. The crude material was subjected to chromatography (100% EtOAc) to yield 3-(4-((8Z,11Z)-heptadeca-8,11-dien-1-yl)-6-((9Z,12Z)-octadeca-9,12-dien-1-yl)-1,3-dioxan-2-yl)-N,N-dimethylpropan-1-amine (9) (399 mg, 68%) as a colorless oil. Rf 0.5 (10% CH3OH—CH2Cl2);

Workup

  1. extractionextracted with CH2Cl2
  2. washThe organic layer was washed with brine
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-3d9345f6f45140178eafb5fcd6afd45b
Source dataset
uspto-grants-2015_09
Patent number
US09126966B2

Reaction notes

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