Allyl bromide → HCID 178460816, compound

HRID 2274723Notes

Reaction equation

HRID 2274723 reaction equation
[NH:1]1[C:5]2[CH:6]=[C:7]([C:10]3[O:14][C:13]([SH:15])=[N:12][N:11]=3)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH2:16](Br)[CH:17]=[CH2:18]>CCO>[CH2:18]([S:15][C:13]1[O:14][C:10]([C:7]2[CH:8]=[CH:9][C:4]3[NH:3][CH:2]=[N:1][C:5]=3[CH:6]=2)=[N:11][N:12]=1)[CH:17]=[CH2:16]

Participants

4

Reactant 2

HCID 7841Allyl bromideHCID 178527937HCID 178527937, compound

Product 1

HCID 178460816HCID 178460816, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 (0.33 g, 1.5 mmol), TEA (0.209 mL, 1.5 mmol) and allylbromide (0.093 mL, 1.5 mmol) were dissolved in 10 mL of EtOH and kept under reflux overnight. The solvent was removed and the remaining oil was purified by flash-chromatography on silica gel, applying a CHCl3/MeOH gradient.

Workup

  1. temperatureunder reflux overnight
  2. customThe solvent was removed
  3. customthe remaining oil was purified by flash-chromatography on silica gel

Sources & evidence

ORD record
ord-5db6ee4eb82f43789011c42c87141df0
Source dataset
uspto-grants-2015_09
Patent number
US09126987B2

Reaction notes

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