Pentafluorobenzyl bromide → HCID 178505969, compound

HRID 2274730Notes

Reaction equation

HRID 2274730 reaction equation
[NH:1]1[C:5]2[CH:6]=[C:7]([C:10]3[O:14][C:13]([SH:15])=[N:12][N:11]=3)[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[F:16][C:17]1[C:22]([CH2:23]Br)=[C:21]([F:25])[C:20]([F:26])=[C:19]([F:27])[C:18]=1[F:28]>CCO>[F:16][C:17]1[C:22]([CH2:23][S:15][C:13]2[O:14][C:10]([C:7]3[CH:8]=[CH:9][C:4]4[NH:3][CH:2]=[N:1][C:5]=4[CH:6]=3)=[N:11][N:12]=2)=[C:21]([F:25])[C:20]([F:26])=[C:19]([F:27])[C:18]=1[F:28]

Participants

4

Reactant 2

HCID 74484Pentafluorobenzyl bromideHCID 178527937HCID 178527937, compound

Product 1

HCID 178505969HCID 178505969, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 (0.33 g, 1.5 mmol), TEA (0.209 mL, 1.5 mmol) and pentafluorobenzylbromide (0.204 mL, 1.5 mmol) were dissolved in 10 mL of EtOH and kept under reflux overnight. The solvent was removed and the remaining oil was purified by flash-chromatography on silica gel, applying a CHCl3/MeOH gradient.

Workup

  1. temperatureunder reflux overnight
  2. customThe solvent was removed
  3. customthe remaining oil was purified by flash-chromatography on silica gel

Sources & evidence

ORD record
ord-b7eb2551479d4f00aeff6a0ac217c30a
Source dataset
uspto-grants-2015_09
Patent number
US09126987B2

Reaction notes

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