反应详情

温度

80 °C

A suspension of compound of Example 1a (1.0 eq) in dioxane (approx 4.5 vol) was treated with thionyl chloride (1.5 eq) and heated to 80° C. A clear solution formed at approximately 75° C. The mixture was stirred for 3 hours at 80° C. Unreacted thionyl chloride was distilled off and after distillation the residue was cooled to 10° C.

1. customA clear solution formed at approximately 75° C
2. distillationwas distilled off
3. distillationafter distillation the residue
4. temperaturewas cooled to 10° C.