Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Hydroxy-3-methoxy-5-nitrobenzoic acid | HCID 15527939 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 89619537 | HCID 89619537 | — |
Reaction Steps
A suspension of compound of Example 1a (1.0 eq) in dioxane (approx 4.5 vol) was treated with thionyl chloride (1.5 eq) and heated to 80° C. A clear solution formed at approximately 75° C. The mixture was stirred for 3 hours at 80° C. Unreacted thionyl chloride was distilled off and after distillation the residue was cooled to 10° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09126988B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-e53b765c64ce4bb39568f77c0a79b5b1 |
|---|
| Source note | uspto-grants-2015_09 |
|---|
