反应详情

温度

0 °C

NaBH4 (215 mg; 5.68 mmol) was added to the solution of benzyl 3-oxocyclobutanecarboxylate (2.3 g; 11.3 mmol) in THF (30 mL) and MeOH (1.5 mL). The reaction mixture was stirred for 0.5 hour at 0° C., diluted with water (20 mL), and extracted with DCM (50 mL×2). The combined organic layers were dried over anhydrous Na2SO4, filtered, concentrated, and purified by reverse phase flash chromatography to afford 1.24 g (53%) of the title compound as a yellow oil.

1. extractionextracted with DCM (50 mL×2)
2. dry with materialThe combined organic layers were dried over anhydrous Na2SO4
3. filtrationfiltered
4. concentrationconcentrated
5. custompurified by reverse phase flash chromatography