6-(Trifluoromethyl)indole → 3-iodo-6-(trifluoromethyl)-1H-indole

HRID 2274784Notes

Reaction equation

HRID 2274784 reaction equation
F[C:2]1[CH:10]=[C:9]2[C:5]([C:6]([I:20])=[CH:7][N:8]2S(C2C=CC=CC=2)(=O)=O)=[CH:4][CH:3]=1.[F:21][C:22]([F:33])([F:32])C1C=C2C(C=CN2)=CC=1>>[I:20][C:6]1[C:5]2[C:9](=[CH:10][C:2]([C:22]([F:33])([F:32])[F:21])=[CH:3][CH:4]=2)[NH:8][CH:7]=1

Participants

3

Reactant 2

HCID 27775236-(Trifluoromethyl)indoleHCID 672798376-fluoro-3-iodo-1-(phenylsulfonyl)-1H-indole

Product 1

HCID 1180606793-iodo-6-(trifluoromethyl)-1H-indoleYield 98%

Procedure

Following the general method as outlined in Intermediate 3, starting from 6-(trifluoromethyl)-1H-indole (0.97 g; 5.24 mmol), 1.60 g (98%) of the title compound was obtained as a red solid, which was used directly without further purification.

Sources & evidence

ORD record
ord-4f51ff963c2a4360820e13464be79b78
Source dataset
uspto-grants-2015_09
Patent number
US09126984B2

Reaction notes

Loading…