5,6-difluoro-3-iodo-1-(phenylsulfonyl)-1H-indole → 3-iodo-1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole

HRID 2274785Notes

Reaction equation

HRID 2274785 reaction equation
FC1C=C2C(=CC=1F)N([S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:14])=[O:13])C=C2I.[I:22][C:23]1[C:31]2[C:26](=[CH:27][C:28]([C:32]([F:35])([F:34])[F:33])=[CH:29][CH:30]=2)[NH:25][CH:24]=1>>[I:22][C:23]1[C:31]2[C:26](=[CH:27][C:28]([C:32]([F:33])([F:35])[F:34])=[CH:29][CH:30]=2)[N:25]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:14])=[O:13])[CH:24]=1

Participants

3

Reactant 2

HCID 1180602835,6-difluoro-3-iodo-1-(phenylsulfonyl)-1H-indoleHCID 1180606793-iodo-6-(trifluoromethyl)-1H-indole2×

Product 1

HCID 1180606073-iodo-1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indoleYield 45%

Procedure

Following the general method as outlined in Intermediate 28, starting from 3-iodo-6-(trifluoromethyl)-1H-indole (Intermediate 39; 1.60 g; 5.14 mmol), 1.06 g (45%) of the title compound was obtained as a yellow solid.

Sources & evidence

ORD record
ord-50b14541b5194c119e1a5499af2d589e
Source dataset
uspto-grants-2015_09
Patent number
US09126984B2

Reaction notes

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