HCID 18471417, compound → HCID 118060369, compound

HRID 2274792Notes

Reaction equation

HRID 2274792 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:20]3[CH:21]=[N:22][NH:23][CH:24]=3)=[CH:7][N:8]2[S:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)(=[O:13])=[O:12])=[CH:4][CH:3]=1.[O:25]1[C:29]2([CH2:34][CH2:33][CH:32](CS([O-])(=O)=O)[CH2:31][CH2:30]2)[O:28][CH2:27][CH2:26]1>>[O:25]1[C:29]2([CH2:34][CH2:33][CH:32]([N:23]3[CH:24]=[C:20]([C:6]4[C:5]5[C:9](=[CH:10][C:2]([F:1])=[CH:3][CH:4]=5)[N:8]([S:11]([C:14]5[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=5)(=[O:12])=[O:13])[CH:7]=4)[CH:21]=[N:22]3)[CH2:31][CH2:30]2)[O:28][CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 18471417HCID 18471417, compoundHCID 1180601346-fluoro-1-(phenylsulfonyl)-3-(1H-pyrazol-4-yl)-1H-indole2×

Product 1

HCID 118060369HCID 118060369, compoundYield 59%

Procedure

Following the general method as outlined in Intermediate 16, starting from 6-fluoro-1-(phenylsulfonyl)-3-(1H-pyrazol-4-yl)-1H-indole (Intermediate 5; 600 mg; 1.76 mmol) and 1,4-dioxaspiro[4.5]decan-8-ylmethanesulfonate (498 mg; 2.11 mmol), 500 mg (59%) of the title compound was obtained as a white solid after purification by reverse phase flash chromatography.

Sources & evidence

ORD record
ord-30a8a4f293874bf38c9ac920f8fbdd84
Source dataset
uspto-grants-2015_09
Patent number
US09126984B2

Reaction notes

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