N,N-Dimethylethylenediamine → HCID 118060497, compound

HRID 2274800Notes

Reaction equation

HRID 2274800 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]3[CH:12]=[N:13][N:14]([CH2:16][CH2:17][C:18]([OH:20])=O)[CH:15]=3)=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH3:21][N:22]([CH3:26])[CH2:23][CH2:24][NH2:25]>>[CH3:21][N:22]([CH3:26])[CH2:23][CH2:24][NH:25][C:18](=[O:20])[CH2:17][CH2:16][N:14]1[CH:15]=[C:11]([C:6]2[C:5]3[C:9](=[CH:10][C:2]([F:1])=[CH:3][CH:4]=3)[NH:8][CH:7]=2)[CH:12]=[N:13]1

Participants

3

Reactant 2

HCID 66053N,N-DimethylethylenediamineHCID 118060153HCID 118060153, compound

Product 1

HCID 118060497HCID 118060497, compoundYield 15%

Procedure

Following the general method as outlined in Example 39, starting from 3-(4-(6-fluoro-1H-indol-3-yl)-1H-pyrazol-1-yl)propanoic acid (Example 24; 110 mg; 0.40 mmol) and N,N-dimethylethylenediamine (0.08 mL; 0.8 mmol), 20 mg (15%) of the title product was obtained as a yellow solid purified by preparative HPLC.

Sources & evidence

ORD record
ord-1e6930cc168047d5ad57b2c7e0b6e52d
Source dataset
uspto-grants-2015_09
Patent number
US09126984B2

Reaction notes

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