Morpholine → HCID 10459581, compound

HRID 227481Notes

Reaction equation

HRID 227481 reaction equation
ClC1C=C2C(=CC=1)[N:7](S(C1C=CC=CC=1)(=O)=O)C(C(OCC)=O)=C2S(Cl)(=O)=O.[Br:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[N:35](S(C1C=CC=CC=1)(=O)=O)[C:34]([C:48]([O:50]CC)=O)=[C:33]2[S:53](Cl)(=[O:55])=[O:54].N1CCOCC1.Cl.[N:64]1([CH2:70][CH2:71][CH2:72][N:73]2[CH2:78][CH2:77][NH:76][CH2:75][C:74]2=[O:79])[CH2:69][CH2:68][O:67][CH2:66][CH2:65]1>>[Br:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[NH:35][C:34]([C:48]([NH2:7])=[O:50])=[C:33]2[S:53]([N:76]1[CH2:77][CH2:78][N:73]([CH2:72][CH2:71][CH2:70][N:64]2[CH2:69][CH2:68][O:67][CH2:66][CH2:65]2)[C:74](=[O:79])[CH2:75]1)(=[O:54])=[O:55]

Participants

5

Reactant 4

HCID 8083MorpholineHCID 22401482ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylateHCID 57445036HCID 57445036, compoundHCID 86592455ethyl 3-(chlorosulfonyl)-5-bromo-1-(phenylsulfonyl)-1H-indole-2-carboxylate

Product 1

HCID 10459581HCID 10459581, compound

Procedure

Following the procedures described in Steps D and E of Example 1, replacing in Step D ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 5-bromo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2carboxylate, and morpholine with 1-(3-morpholin-4-ylpropyl)piperazin-2-one hydrochloride, the title compound was obtained. ESI+MS: 528.3 [M+H]+.

Sources & evidence

ORD record
ord-550823dd0ea944929fdbd440cf97e679
Source dataset
uspto-grants-2009_07
Patent number
US07560546B2

Reaction notes

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