HRID227481

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8083

Morpholine

C4H9NO

反应SMILES：CCOC(=O)c1c(S(=O)(=O)Cl)c2cc(Cl)ccc2n1S(=O)(=O)c1ccccc1

HCID22401482

未命名化合物

HCID57445036

未命名化合物

反应SMILES：CCOC(=O)c1c(S(=O)(=O)Cl)c2cc(Br)ccc2n1S(=O)(=O)c1ccccc1

HCID86592455

未命名化合物

PRODUCTS

产物

反应SMILES：NC(=O)c1[nH]c2ccc(Br)cc2c1S(=O)(=O)N1CCN(CCCN2CCOCC2)C(=O)C1

HCID10459581

未命名化合物

PROCEDURE

实验过程

Following the procedures described in Steps D and E of Example 1, replacing in Step D ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 5-bromo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2carboxylate, and morpholine with 1-(3-morpholin-4-ylpropyl)piperazin-2-one hydrochloride, the title compound was obtained. ESI+MS: 528.3 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-550823dd0ea944929fdbd440cf97e679
来源数据集: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07560546B2
来源说明: uspto-grants-2009_07

反应SMILES

ClC1C=C2C(=CC=1)[N:7](S(C1C=CC=CC=1)(=O)=O)C(C(OCC)=O)=C2S(Cl)(=O)=O.[Br:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[N:35](S(C1C=CC=CC=1)(=O)=O)[C:34]([C:48]([O:50]CC)=O)=[C:33]2[S:53](Cl)(=[O:55])=[O:54].N1CCOCC1.Cl.[N:64]1([CH2:70][CH2:71][CH2:72][N:73]2[CH2:78][CH2:77][NH:76][CH2:75][C:74]2=[O:79])[CH2:69][CH2:68][O:67][CH2:66][CH2:65]1>>[Br:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[NH:35][C:34]([C:48]([NH2:7])=[O:50])=[C:33]2[S:53]([N:76]1[CH2:77][CH2:78][N:73]([CH2:72][CH2:71][CH2:70][N:64]2[CH2:69][CH2:68][O:67][CH2:66][CH2:65]2)[C:74](=[O:79])[CH2:75]1)(=[O:54])=[O:55]