HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanecarboxylic acid → HCID 118060557, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanecarboxylic acid | HCID 15655 | — |
| Reactant | 6-fluoro-1-(phenylsulfonyl)-3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-indole hydrochloride | HCID 118060305 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 118060557 | HCID 118060557 | 107.8% |
Reaction Steps
Following the general method as outlined in Example 83, starting from 6-fluoro-1-(phenylsulfonyl)-3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-indole hydrochloride (Intermediate 17; 300 mg; 0.65 mmol) and cyclopropanecarboxylic acid (122 mg; 1.42 mmol) in DMF (6 mL), 345 mg of the title compound was obtained as a yellow oil, which was used directly without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126984B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-95c4aec7adc648bf96a19b04180fe5ce |
| Source note | uspto-grants-2015_09 |