Cyclopropanecarboxylic acid → HCID 118060557, compound

HRID 2274837Notes

Reaction equation

HRID 2274837 reaction equation
Cl.[F:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7]([C:21]3[CH:22]=[N:23][N:24]([CH:26]4[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]4)[CH:25]=3)=[CH:8][N:9]2[S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:14])=[O:13])=[CH:5][CH:4]=1.[CH:32]1([C:35](O)=[O:36])[CH2:34][CH2:33]1>CN(C=O)C>[CH:32]1([C:35]([N:29]2[CH2:30][CH2:31][CH:26]([N:24]3[CH:25]=[C:21]([C:7]4[C:6]5[C:10](=[CH:11][C:3]([F:2])=[CH:4][CH:5]=5)[N:9]([S:12]([C:15]5[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=5)(=[O:13])=[O:14])[CH:8]=4)[CH:22]=[N:23]3)[CH2:27][CH2:28]2)=[O:36])[CH2:34][CH2:33]1

Participants

4

Reactant 2

HCID 15655Cyclopropanecarboxylic acidHCID 1180603056-fluoro-1-(phenylsulfonyl)-3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-indole hydrochloride2×

Product 1

HCID 118060557HCID 118060557, compoundYield 107.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Following the general method as outlined in Example 83, starting from 6-fluoro-1-(phenylsulfonyl)-3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-indole hydrochloride (Intermediate 17; 300 mg; 0.65 mmol) and cyclopropanecarboxylic acid (122 mg; 1.42 mmol) in DMF (6 mL), 345 mg of the title compound was obtained as a yellow oil, which was used directly without further purification.

Sources & evidence

ORD record
ord-95c4aec7adc648bf96a19b04180fe5ce
Source dataset
uspto-grants-2015_09
Patent number
US09126984B2

Reaction notes

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