Hydrochloric Acid → HCID 44384052, compound

HRID 2274945Notes

Reaction equation

HRID 2274945 reaction equation
[CH2:1]([N:8]1[C:16]2[CH2:15][CH2:14][N:13](C(=O)C)[CH2:12][C:11]=2[C:10]([C:20]2[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C(O)C>[CH2:1]([N:8]1[C:16]2[CH2:15][CH2:14][NH:13][CH2:12][C:11]=2[C:10]([C:20]2[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 76850843HCID 76850843, compound

Product 1

HCID 44384052HCID 44384052, compoundYield 79.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 1-[1-Benzyl-3-(4-fluoro-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-ethanone (6e) (6.9 g, 20 mmol), ethanol (73 ml) and 10N aqueous HCl (137 ml) was stirred at 80° C. for 2 h and then overnight at room temperature. The mixture was concentrated in vacuo and the product was filtrated off and washed with a small amount of cold water to give 4.87 g of 1-Benzyl-3-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine; hydrochloride (7b).

Workup

  1. customovernight
  2. customat room temperature
  3. concentrationThe mixture was concentrated in vacuo
  4. filtrationthe product was filtrated off
  5. washwashed with a small amount of cold water

Sources & evidence

ORD record
ord-5002d9a3fc404460b515f68a0d1b2079
Source dataset
uspto-grants-2015_09
Patent number
US09127001B2

Reaction notes

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