Hydrochloric Acid → HCID 90028139, compound

HRID 2275035Notes

Reaction equation

HRID 2275035 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([C:10]2[CH:30]=[CH:29][C:13]3[N:14]([CH3:28])[C:15]([C:17]4[N:25]([CH2:26][CH3:27])[C:20]5=[N:21][CH:22]=[CH:23][CH:24]=[C:19]5[CH:18]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH2:3]1.[ClH:31]>CO>[ClH:31].[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([C:10]2[CH:30]=[CH:29][C:13]3[N:14]([CH3:28])[C:15]([C:17]4[N:25]([CH2:26][CH3:27])[C:20]5=[N:21][CH:22]=[CH:23][CH:24]=[C:19]5[CH:18]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 73052771HCID 73052771, compound

Product 1

HCID 90028139HCID 90028139, compoundYield 74.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(R)-(3-aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-1-methyl-1H-benzo[d]imidazol-5-yl)methanone (170 mg) was taken up in MeOH (5 mL) and treated with HCl (1M in ether) (165 μL) and blown down under nitrogen to give (R)-(3-aminopiperidin-1-yl)(2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-1-methyl-1H-benzo[d]imidazol-5-yl)methanone, hydrochloride (187 mg, 0.43 mmol, 74.2% yield) as a cream solid.

Sources & evidence

ORD record
ord-b60f48c68068498dac92a225fbe86d40
Source dataset
uspto-grants-2015_09
Patent number
US09127003B2

Reaction notes

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