Benzaldehyde → HCID 57756132, compound

HRID 227504Notes

Reaction equation

HRID 227504 reaction equation
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:18]=1[NH:17][C:16]([C:19]([NH2:21])=[O:20])=[C:15]2[S:22]([N:25]1[CH2:30][CH2:29][O:28][C@H:27]([CH2:31][O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH2:26]1)(=[O:24])=[O:23]>>[CH2:1]([NH:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:18]=1[NH:17][C:16]([C:19]([NH2:21])=[O:20])=[C:15]2[S:22]([N:25]1[CH2:30][CH2:29][O:28][C@H:27]([CH2:31][O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH2:26]1)(=[O:24])=[O:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 240BenzaldehydeHCID 10432835HCID 10432835, compound

Product 1

HCID 57756132HCID 57756132, compound

Procedure

Using the method described in Example 85, replacing 4-formylpyridine with benzaldehyde, 7-Amino-3-{[(2S)-2-(phenoxymethyl)morpholin-4-yl]sulfonyl}-1H-indole-2-carboxamide was converted to the titled product. Proton NMR for the product was consistent with the titled compound. HRMS (ES) exact mass calculated for C27H29N4O5S (M+H+): 521.1853. Found 521.1856.

Sources & evidence

ORD record
ord-103f0037f80f4b26badc0aa63aa9b78e
Source dataset
uspto-grants-2009_07
Patent number
US07560546B2

Reaction notes

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