Hydrochloric Acid → (R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone, hydrochloride

HRID 2275049Notes

Reaction equation

HRID 2275049 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([C:10]2[CH:33]=[C:32]([O:34][CH3:35])[C:13]3[N:14]([CH3:31])[C:15]([C:17]4[N:25]([CH2:26][C:27]([F:30])([F:29])[F:28])[C:20]5=[N:21][CH:22]=[CH:23][CH:24]=[C:19]5[CH:18]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH2:3]1.[ClH:36]>C(Cl)Cl>[ClH:36].[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([C:10]2[CH:33]=[C:32]([O:34][CH3:35])[C:13]3[N:14]([CH3:31])[C:15]([C:17]4[N:25]([CH2:26][C:27]([F:30])([F:29])[F:28])[C:20]5=[N:21][CH:22]=[CH:23][CH:24]=[C:19]5[CH:18]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 73052940(R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone

Product 1

HCID 131733421(R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone, hydrochlorideYield 102.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone (1.5073 g) was dissolved in DCM (5 ml) and HCl (2M in diethyl ether) (1.5 ml, 3.00 mmol) was added to the solution. The solvent was then removed under nitrogen and concentrated under vacuum to afford the title compound as a white solid (1.61 g)

Workup

  1. customThe solvent was then removed under nitrogen
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-b7ce77abccff4a6b8331b11354f0e5dc
Source dataset
uspto-grants-2015_09
Patent number
US09127003B2

Reaction notes

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