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HRID2275054

反应详情

EQUATION

反应方程式

HRID 2275054 的结构方程式

REACTANTS

反应物

2
结构：O=S(=O)(O)O
HCID1118

Sulfuric acid

H2O4S

结构：CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5
HCID5288826

Morphine

C17H19NO3

PRODUCTS

生成物

1
结构：CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5.O.O.O.O.O.O=S(=O)(O)O
HCID6436139

Sulfuric acid--17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol--water (1/1/5)

C17H31NO12S

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度
55 °C

PROCEDURE

实验过程

Morphine free base material (AMA) from Example 4 (19 ppm ABUK) and water were mixed, heated to 55° C. and the pH was determined to be 7.75. The following titration was performed using sulfuric acid (51%) as the temperature was increased to about 65° C.

WORKUP

后处理

  1. temperaturewas increased to about 65° C.