Methanol → Methyl 2-fluoro-3-iodo-4-methylbenzoate

HRID 2275419Notes

Reaction equation

HRID 2275419 reaction equation
[F:1][C:2]1[C:10]([I:11])=[C:9]([CH3:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[CH3:18]O>>[CH3:18][O:5][C:4](=[O:6])[C:3]1[CH:7]=[CH:8][C:9]([CH3:12])=[C:10]([I:11])[C:2]=1[F:1]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 593839002-Fluoro-3-iodo-4-methylbenzoic acid

Product 1

HCID 67211177Methyl 2-fluoro-3-iodo-4-methylbenzoate

Conditions

Temperature
90 °C

Procedure

In a 500 ml one-neck flask equipped with a magnetic stir-bar and condenser was added 2-fluoro-3-Iodo-4-methyl-benzoic acid (31.5 g, 112.5 mmol), 250 ml of methanol and 10 ml of sulfuric acid. The reaction was heated at 90° C. overnight.

Workup

  1. customIn a 500 ml one-neck flask equipped with a magnetic stir-bar and condenser

Sources & evidence

ORD record
ord-f2ac138954ce499280eedf966c53f0fa
Source dataset
uspto-grants-2015_09
Patent number
US09127024B2

Reaction notes

Loading…