HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromoaniline → Acridine, 2,9-diamino-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromoaniline | HCID 7807 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 57859223 | HCID 57859223 | — |
| Product | Acridine, 2,9-diamino- | HCID 31624 | — |
Reaction Steps
Ullmann reaction (Step 1) of 2-chlorobenzoic acid 1 and 4-bromoaniline 2 afforded 4′-bromodiphenylamine-2-carboxylic acid 3. Cyclisation with POCl3 followed by amination gave the expected 3-bromo-9-aminoacridine 5 in good yield and purity.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09127164B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-5e7fb896412b42a0a38279209d9cacd2 |
| Source note | uspto-grants-2015_09 |