反应详情

温度

50 °C

2-Amino-6-chlorobenzoic acid (30 g) was suspended in 1,4-dioxane (225 ml) and ethyl chloroformate (75 ml) was added. The mixture was heated at reflux for 1 hour, then cooled to 50° C., and acetyl chloride (75 ml) was added. The mixture was stirred for 10 hours, after which the precipitated product was filtered off and washed with toluene. Drying in vacuum yields 5-chloroisatoic anhydride (33 g, 97% yield).

1. temperatureThe mixture was heated
2. temperatureat reflux for 1 hour
3. filtrationafter which the precipitated product was filtered off
4. washwashed with toluene
5. customDrying in vacuum