反应详情

温度

140 °C

3-Methoxy-6-(tetrahydroquinoline-1-sulfonyl-pyridazine. A mixture of 3-fluorosulfonyl-6-methoxypyridazine (2 mmol, 384 mg) and tetrahydroquinoline (4 mmol, 532 mg) was heated at 140° C. for two hours. The reaction mixture was cooled, extracted with EtOAc (20 mL), and the EtOAc extract was dried, filtered and evaporated to obtain 3-methoxy-6-(tetrahydroquinoline-1-sulfonyl)-pyridazine (73%, 451 mg).

1. temperatureThe reaction mixture was cooled
2. extractionextracted with EtOAc (20 mL)
3. extractionthe EtOAc extract
4. customwas dried
5. filtrationfiltered
6. customevaporated