HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,3,4-Tetrahydroquinoline → 3-Methoxy-6-(tetrahydroquinoline-1-sulfonyl)-pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| Reactant | 3-Fluorosulfonyl-6-methoxypyridazine | HCID 11030636 | — |
| Reactant | Tetrahydroquinoline-1-sulfonyl-pyridazine | HCID 86589093 | — |
| Product | 3-Methoxy-6-(tetrahydroquinoline-1-sulfonyl)-pyridazine | HCID 69049988 | 73% |
Reaction Conditions
| Temperature | 140 °C |
|---|
Reaction Steps
3-Methoxy-6-(tetrahydroquinoline-1-sulfonyl-pyridazine. A mixture of 3-fluorosulfonyl-6-methoxypyridazine (2 mmol, 384 mg) and tetrahydroquinoline (4 mmol, 532 mg) was heated at 140° C. for two hours. The reaction mixture was cooled, extracted with EtOAc (20 mL), and the EtOAc extract was dried, filtered and evaporated to obtain 3-methoxy-6-(tetrahydroquinoline-1-sulfonyl)-pyridazine (73%, 451 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06849629B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-676384e4c29d4a74a0018de6aa100369 |
| Source note | uspto-grants-2005_02 |