Acetonitrile → HCID 86661413, compound

HRID 2275645Notes

Reaction equation

C(N(CC)C(C)C)(C)C.Cl.[CH2:11]1[C:15]2([CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[CH2:14][CH2:13][N:12]1[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22].C(#N)C.[CH3:31][S:32](Cl)(=O)=O>>[CH3:31][S:32][N:18]1[CH2:17][CH2:16][C:15]2([CH2:11][N:12]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:13][CH2:14]2)[CH2:20][CH2:19]1

Participants

Reactant 4

HCID 6342Acetonitrile

HCID 31297Methanesulfonyl chloride

HCID 81531Diisopropylethylamine

HCID 666620882-Boc-2,8-Diazaspiro[4.5]decane hydrochloride

Product 1

HCID 86661413HCID 86661413, compound

Procedure

N,N-Diisopropylethylamine (30.0 μL, 0.000172 mol) was added to tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate hydrochloride (18.5 mg, 0.0000668 mol) in acetonitrile (1.0 mL, 0.019 mol), followed by methanesulfonyl chloride (10.0 μL, 0.000129 mol). After stirring for 1 h the solvent was evaporated, and the residue was dried under high vacuum and was used in the next step without further purification.

Workup

customwas evaporated
customthe residue was dried under high vacuum
customwas used in the next step without further purification

Sources & evidence

ORD record: ord-ca66bc2ee4d14dbb9e08d81864c1284e
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09126927B2

Reaction notes

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