Hydrochloric Acid → 869976-51-2

HRID 2275656Notes

Reaction equation

HRID 2275656 reaction equation
[C:1]([C:5]1([OH:17])[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)([CH3:4])([CH3:3])[CH3:2].O1CCOCC1.[ClH:24]>>[ClH:24].[C:1]([C:5]1([OH:17])[CH2:9][CH2:8][NH:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66662233HCID 66662233, compound

Product 1

HCID 66662240869976-51-2

Procedure

tert-Butyl 3-tert-butyl-3-hydroxypyrrolidine-1-carboxylate (0.60 g, 0.0025 mol) was dissolved in a solution of hydrogen chloride in 1,4-dioxane (4N, 0.30 mL, 0.0099 mol) under N2 at rt. The reaction mixture was stirred for 3 h at rt, then concentrated in vacuo. The crude product was used directly in the next step without further purification, (M+H) 144.1

Workup

  1. concentrationconcentrated in vacuo
  2. customThe crude product was used directly in the next step without further purification, (M+H) 144.1

Sources & evidence

ORD record
ord-d94c48da737f4d6c857d7cb73586e1c1
Source dataset
uspto-grants-2015_09
Patent number
US09126927B2

Reaction notes

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